Parkinson’s

 

Hi Ron. I wanted to give you an update on John’s dad. He’s been taking the Sativa now, 5 drops on a spoon held under the tongue, for over 2 weeks and he is responding very well. He called us today and shared he has noticed considerable improvement with his shaking and balance. He has been using a walker since his fall in December and his doctor said he no longer needs a walker and only wants him using a cane. Pretty incredible to be 88 with Parkinson’s and being told you are getting better! Thanks so much for all of your advice and guidance!

Thank you Susan for sending me this message. Messages like these really make us happy here to know that our extracts are helping your father in law.

Cannabidiol (CBD) has been the focus of many medical cannabis studies, and continues to prove itself as a powerful anti-inflammatory drug. What makes CBD even more desirable for some patients is that it does not cause the psychoactive effects associated with tetrahydrocannabinol (THC).

An extremely interesting study (Overcoming the Bell-Shaped Dose-Response of Cannabidiol by using Cannabis Extract Enriched in Cannabidiol) was just published out of the Lautenberg Center for General and Tumor Immunology in Jerusalem. The study examines the effectiveness of administering isolated cannabinoid extracts (a CBD-only formula) versus whole plant extracts (which contain the full range of the plant’s cannabinoid content).

Cannabis Testing on Mice (AP Photo/Robert F. Bukaty)
Results Of CBD vs. Full-Spectrum on Inflammation and Pain

The Hadassah Medical School at the Hebrew University of Jerusalem sought to compare the effectiveness of a completely purified CBD extract versus a full-spectrum extract of cannabis flowers containing large quantities of CBD. The conclusion of the study was that the whole plant extract, which contained a large percentage of CBD but also contained traces of the other cannabinoids, proved far more effective than CBD-only solutions in alleviating inflammation and pain sensation. The study demonstrated that a whole plant extract, containing the entire range of cannabinoids present in raw cannabis, will continue to provide relief for inflammation as the dose is increased. When supplied as an isolated cannabinoid extract, CBD on its own yielded a bell-curve of effectiveness, which is not desirable for medical treatments seeking effective relief that corresponds with the dosage.

Materials Used: Plants, Animals, and Extracts

The purified CBD was acquired from THC Pharm. GmbH (Frankfurt, Germany) to act as the pharmaceutical grade isolated extract. For the whole plant extract, flowers from the clone 202 (proprietary strain: Avidekel) were supplied by the government-approved growers Tikun Olam Company. Bred to be rich in CBD, the raw flowers of this whole plant extract were ground up and cannabinoids were extracted using the solvent ethanol. The pure CBD extract and the full-spectrum extract were formulated for both injection and oral administration. The tests were performed on ethically-approved lab mice from Hadassah Medical School. In addition to a control group, the commercial drugs aspirin and tramadol were used on separate sets of mice to further compare the effectiveness of synthetic isolations versus whole plant extracts. The study was represented by 10-12 mice per treatment group, using known laboratory methods for measuring reductions in inflammation and pain sensation (described at length in the study). The results clearly show the medical benefit of extracting all the different compounds from the entirety of the raw cannabis flower, rather than extraction of a single cannabinoid.

The data graphs below compare isolated cannabidiol (CBD) against a full-spectrum cannabis extract (from a CBD-rich strain). In all of the tests, the isolated CBD was ineffective both before and after a certain dosage, while the effectiveness of the full-spectrum solution continued to increase as higher doses were administered. The results all indicate that CBD is only effective against swelling and pain at a certain dose, and that cannabis solutions containing a full range of cannabinoids will continue to provide corresponding effects as the dosage is increased.

Injections: The isolated CBD injection was moderately effective at 5 mg/kg, but became less effective when the dose was higher. The shape of the graph resembles a bell-curve, indicating that the CBD-only formula lost effectiveness after a certain dose. The results from the cannabis flower extract showed that the synergy between the cannabinoids yielded greater relief as the dosage was increased, which is desirable in medicine.

See full article here: https://www.cannabisreports.com/news/2015/03/09/cannabis-study-full-spectrum-cannabis-extracts-more-medically-effective-than-cbd-alone/

Kristin Wohlschlagel

Sad outcome to what I considered a valid lawsuit. Keeping cannabis in Schedule 1 includes a statement that it has no medicinal value. This is clearly not true. Whether or not people agree about “how” medicinal it is, I believe many have realized medicinal value. Thank you, especially, to Alexis Bortell, for carrying the torch so high. Oddly, the judge made it clear that he accepted her claim that it had medicinal value, so that is something. But he said they had not exhausted their administrative options, which appears to mean appealing to Attorney General Jeff Sessions. Time to regroup and look at new targets for efforts to focus on to fix this.

Perhaps focusing efforts on the Controlled Substances Act: https://www.dea.gov/druginfo/csa.shtml

As it is the Attorney General who apparently holds all the power to change status or remove a substance from the CSA, we all need to put pressure on Jeff Sessions or push to have him replaced if he continues to keep cannabis as Schedule 1. How someone with no medical training can hold all the power over deciding things like this is deeply concerning. https://www.deadiversion.usdoj.gov/21cfr/21usc/811.htm

In case you were wondering who appoints the Federal Attorney General, it is the president. So Donald Trump appointed Jeff Sessions and he was confirmed by Congress. So this is ultimately up to Donald Trump. I think a Twitter campaign is in order as this is apparently a favorite mode of communication. https://en.wikipedia.org/wiki/United_States_Attorney_General

Please remember that our U.S. government holds an actual patent since 1998, supported by research done by the US Dept. of Health and Human Services, on cannabinoids as therapeutic for neurodegenerative, ischemic stroke and autoimmune diseases, yet keeps the cannabis plant, *which is the inspiration even for the names of these molecules*, in Schedule 1 which claims no medicinal value. To me, this seems a valid argument against Schedule 1 status.

https://patents.google.com/patent/US6630507 Here is an actual quote from this patent: “This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases.” It also mentions that: “THC (tetrahydrocannabinol) is another of the cannabinoids that has been shown to be neuroprotective in cell cultures, but this protection was believed to be mediated by interaction at the cannabinoid receptor, and so would be accompanied by undesired psychotropic side effects.”

So, the US Health and Human Services agency clearly states it is useful in the treatment and prophylaxis, but it is still in Schedule 1, which effectively suppresses research on it which could rapidly clarify how to refine the use of cannabinoids therapeutically? Sigh…

Isolated or synthetic cannabinoids, ironically only synthetic THC made by a pharmaceutical company, yet is the exact same molecule in the plant — but considered illegal from that source, are considered medicinal, but the exact same molecules in a plant are considered without medicinal value and as dangerous as heroin?

I cannot help but believe the powerful pharmaceutical industry is behind much of this insanity, followed closely by drug enforcement agencies and private prison industry lobbyists for resisting a rational and compassionate change. Our healthcare system is sadly almost completely driven by the profit motive as is our research into medicine development. We are completely dependent on pharmaceutical companies to fund and conduct research to develop new treatments, yet they will not spend their dollars on this because, if they spend millions to research therapeutic potential, people will be able to grow a plant that can potentially be used to achieve those therapeutic results. What a corrupt pickle we are in.

So, for the time being, Donald Trump and AG Jeff Sessions are the only ones who can change the Federal Schedule 1 status of cannabis. I have tweeted to Donald Trump. As many have tried and failed to make any progress by reaching out to Jeff Sessions with lawsuits, it seems difficult to hold out hope that he may change his stance. But perhaps I need to suppress that thought and try anyway. As hard as it seems, perhaps many clear, non-insulting and rational requests from patients may eventually reach him and help him to change his understanding of the profound benefits they have found when using cannabis medicines. I know this may seem very naive of me but I see this as one of the only options we Americans have to change the Schedule 1 status. Just because it seems unlikely to succeed, does not mean we should stop trying to use the mechanism in place to effect that change. Here is the official page to contact his department: https://www.justice.gov/…/your-message-department-justice

Federal Judge Dismisses Marijuana Lawsuit

Cancer is a curable disease provided it is diagnosed early. However a better option would be to pro actively manage and prevent the birth and multiplication of cancer cells. The following 12 cancer fighting foods could be very useful in preventing the dreaded disease taking roots in the body.

Green Leafy Vegetables
Most green leafy vegetables such as spinach and broccoli can help a lot in forming a preventive barrier against growth of cancerous cells. This is because these green leafy vegetables are an excellent source of vitamins, minerals and antioxidants.

Cruciferous Vegetables
Cruciferous vegetables for many decades are considered to be excellent anti-cancer foods. This is because they are again a rich source of many antioxidants in general and glutathione in particular. This could help in preventing growth of cancerous cells and tumors.

Berries
When we talk about berries we are referring to a special categories of fruits which have very high ORAC scores. Hence consumption of these berries on a regular could have an impact in reducing the risk of cancer cells.

Orange Colored Fruits
Oranges, sweet potatoes and a few other orange colored fruits are known to be extremely beneficial in fighting cancer cells and preventing them from forming into tumors in the body.

Spices And Related Items
There are many herbs and spices which have excellent anti-cancer properties and have been used for generations. These include raw garlic, ginger, basil, parsley, cayenne pepper and organo.

Organic Meats
Beef and chicken liver are often considered to be excellent sources of vitamins and minerals which could form an antioxidant layer in the body. It could also help in preventing formation of cancerous tumors.

Cultured Dairy Products
There are quite a few cultured dairy products which are rich in different types of probiotics. They help not only in keeping the gut clean but also have many good bacteria which could be helpful in preventing cancer of the intestine, stomach and other parts of the body.

Nuts And Seeds
Nuts and seeds are rich in omega-3 fatty acids and therefore they could help in preventing cancer. There are many such nuts and seeds including chia seeds, flax seeds and hemp seeds. Cashew nuts can also be a regular food.

Unrefined Natural Oils
Coconut oil, olive oil and sesame oil are excellent naturally occurring oils which are very useful in combating different types of cancers of the body.

Mushrooms
Certain types of mushrooms such as cordyceps, maitake and reishi are known to have very good anti-cancer properties because they are rich in antioxidants.

Traditional Teas
Green tea and other types of natural teas have been used as herbs for the purpose of boosting immune levels and this in turn could help to lower the risk of growth of cancerous cells.

Wild Fish
Cod fish and sardines are excellent sources omega-3 fatty acids which have high concentration antioxidants that could help in preventing formation of cancerous cells.

Reference Links: http://www.recommendedthings.com/top-12-cancer-fighting-foods/

Brubroth.com

10/8/2017
0 COMMENTS

By Janna Champagne, BSN, RN
I was first introduced to the topic of Epigenetics in 2008 at a business conference in Florida, and as a medical professional I was immediately intrigued. Epigenetics is defined as the environmental impact on gene expression, which explains how genes can be influenced to alter our genetic health expression (like an on/off switch).
Depending on the environmental factors, this interaction may result in positive (i.e.: nutrition) or negative (ie: toxic exposure) impacts on our health. Very exciting as this exemplifies that our overall health is not determined solely based on what our parents contributed. Instead we as individuals have the ability to positively affect our inherited risk factors for familial diseases, by applying components that exert a beneficial influence on our genetic predisposition (1).
Correctly applied Nutrigenomics (genetically-individualized nutrition) is one example with the potential to improve your genetic predisposition to illness, and halt many contributing factors of disease states (1). Basically, this means that positive environmental influences can switch off gene expression that may contribute to illness. This supports what we’ve known for a long time: that given what it needs, the body can balance and heal itself.
Over the years of helping clients optimize their health through nutrigenomics, I’ve seen some amazing results including successful weaning off harmful pharmaceuticals, and reversals of difficult to treat conditions (ie: cancer, autoimmune). My knowledge of Epigenetics has has since crossed over another area of passion: medical cannabis therapy.
Contrary to it’s abhorrent social reputation the last century or so, cannabis is proving to be a source of vital nutrients needed to maintain balance in the body, and is therefore a perfect compliment to almost any nutrigenomic regimen. Of course, unique varieties of cannabis exert varying effects on individuals, an issue that may be solved through a new process that allows for genetic individualization of cannabis therapy.
As you may have already guessed, the subject of genetically guided cannabis therapy is very cutting edge and a bit complex. It’s the overlap of several emerging sciences combined: the endocannabinoid system, human genetics, cannabis genetics and botany are all in the mix. If this intrigues you, then you’re definitely a kindred cannabis nerd.
Here’s a little background info: All humans have an Endocannabinoid System (ECS), which is so important that it’s widely argued that life would not be possible without this master control system (1). The ECS produces endocannabinoids that interact with our ECS receptors, which then work to promote overall balance throughout our bodies. Endocannabinoids are even found in breastmilk, and research supports that they promote newborn survival, making them a vital nutrient for humans (4).
The role of the ECS is homeostasis or balance, and the underlying cause of most chronic illness is imbalance(s) (2). Endocannabinoid deficiency is exemplified in research as a leading underlying cause of chronic illness, reflecting that rampant underlying imbalances in the body contribute to every chronic illness state (5). Cannabis supplementation can help fill the nutrient gaps created by endocannabinoid deficiency, while promoting homeostasis in the area(s) of imbalance, thereby potentially improving this contributing factor.
This explains how cannabis therapy may be beneficial in those suffering a chronic illness, and from experience it’s often more helpful than pharmaceuticals (which have harmful side effects and rarely promote true healing). That’s because the cannabis plant contains the most prolific source of phytocannabinoids, which are able to improve endocannabinoid deficiency symptoms by activating the human ECS. Phytocannabinoids from the cannabis plant exactly mimic the endocannabinoids we produce internally, making cannabis a common sense approach to improving chronic illness outcomes (3).
Endocannabinoid deficiency is especially prevalent in today’s society thanks to nearly a century of cannabis prohibition. The ECS deficiency state often results from a perfect storm of individual gene mutations negatively influencing ECS receptors, along with lacking intake of vital cannabinoid nutrients (ie: cannabis).
Each individual has a unique genetic profile that specifically reflects which cannabinoids may be deficient, representing limitless combinations of optimal cannabis formulations. The cannabis plant contains 144 cannabinoids and 200+ terpenes, thereby providing a broad spectrum of the cannabinoids needed to fill an individual’s ECS deficiency profile (6).
Assessing an individual’s genetics specific to the Endocannabinoid System (including other system pathways that overlap) helps to guide cannabis therapy. Using genetic information to formulate a unique cannabis blend can decrease the “trial and error” phase upon starting cannabis, and provide more consistency in improving patient outcomes.
There are several pathways assessed to determine which cannabis components might best fit an individual’s needs, and genes considered include those from the following pathways (6):
-Serotonin/Dopamine and GABA/Glutamate -Neurotransmitter pathways (cannabinoid profiling, terpene guidance) 9
-Vitamin d3/gcmaf (ECS receptors affected) 10
-Choline pathways (mutation predispose ECS deficiency) 11
-Immune system pathways (for targeted cannabinoid therapy) 12
-AKT1/Schizophrenia predisposition-only known contraindication to THC (13)
-Methylation pathways (addressing mutations mitigates risk factors) 7
and many more…
Genetics are important, but it’s equally imperative to work with a medical professional that understands the basis of the individual’s condition(s), plus any other unique considerations such as medications, symptoms, and lifespan risk factors. Mitigating as many contributing factors as possible, balancing risk vs benefit, and assessing client goals as a holistic process reinforces optimal medical outcomes.
This process of genetic screening is especially important in pediatric applications of cannabis therapy, because methylation pathway mutations predispose neurodevelopmental risks with childhood/adolescent use of cannabis (7). Methylation mutations are linked with chronic illness (the main reason most seek cannabis therapy for a minor child), and these mutations also increase the risk for neurological deficits with cannabis use, making this is a common consideration for minors who may benefit from cannabis therapy.
TO BE VERY CLEAR: This doesn’t mean that children and adolescents with methylation issues shouldn’t use medical cannabis when it’s indicated. Instead this supports that methylation should be optimized with targeted supplementation (nutrigenomics) to mitigate this risk factor. This legitimizes the importance of genetic screening for methylation mutations, especially in children and adolescents that may benefit from cannabis therapy.
What is methylation exactly? The technical term methylation is used to describe a chemical reaction where a methyl donor is required for optimal completion of the chemical cycle. When a person has a methylation mutation (ie: mthfr), the result is a deficiency in methyl donors, which are required for a wide variety of mechanisms in the body. Common results of methyl donor deficiency include inflammation, and dysfunction in both the immune system and detoxification ability (8).
Luckily there are knowledgeable medical nutrigenomic practitioners (like myself) who are able to advise how to decrease this methylation/cannabis pediatric risk factor, through genetic screening that is accessible to most everyone. The cost of testing is affordable, and in the form of a saliva kit submitted by mail, which doesn’t require a physician order.
One more aspect I want to touch on, from my holistic nurse perspective of addressing as many contributing factors as possible. In addition to applying epigenetic screening to guide cannabis therapy, full genome testing can be used to optimize many additional pathway mutations implicated in chronic illness states.
My favorite analogy to describe the potential of combining nutrigenomics and cannabis therapy is a sink that’s overflowing with imbalances, leading to illness symptoms. Starting cannabis therapy helps the body start balancing, and can be likened to taking the plug out of the drain in this overflowing sink scenario. Applied nutrigenomics can turn off the running faucet. Powerful duo for chronic illness indeed.
My hope is to spread knowledge about this very pertinent issue, so that patients and medical professionals alike are aware of the power of using human genetics to guide cannabis therapy. I truly believe this represents the future of cannabis as medicine, which offers our best possibility for healing the widespread chronic illness found in our society today.
Blessings,
Nurse Janna
www.integratedholisticcare.com
References
1. Watters, E.(2008) DNA is not destiny. Accessed online at: http://www.geneimprint.com/media/pdfs/1162334912_fulltext.pdf
2. Piomeli, Daniele (2002). The molecular logic of endocannabinoid signaling. Nature Reviews Neuroscience 4, 873-884 (November 2003). https://www.nature.com/nrn/journal/v4/n11/full/nrn1247.html
3. Department of Chemistry, Kennesaw State University, 1000 Chastain Road, Kennesaw, GA 30144, USA (2002). Endocannabinoid structure-activity relationships for interaction at the cannabinoid receptors. Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):143-60. https://www.ncbi.nlm.nih.gov/pubmed/12052032
4. Grant, I., & Cahn, B. R. (2005). Cannabis and endocannabinoid modulators: Therapeutic promises and challenges. Clinical Neuroscience Research, 5(2-4), 185–199. http://doi.org/10.1016/j.cnr.2005.08.015
5. Smith, SC, Wagner, MS(2014). Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinol Lett. 2014;35(3):198-201. https://www.ncbi.nlm.nih.gov/pubmed/24977967
6. DiMarzo, V., Lutz. B.(2014). Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology. http://onlinelibrary.wiley.com/doi/10.1002/9781118451281.ch4/summary
7.Neuroscience & Biobehavioral Reviews. High times for cannabis: Epigenetic imprint and its legacy on brain and behavior. Neuroscience & Biobehavioral Reviews, May 12, 2017. http://www.sciencedirect.com/science/article/pii/S0149763417300659
8. Lertratanangkoon K, Wu CJ, Savaraj N, Thomas ML. Alterations of DNA methylation by glutathione depletion. Cancer Lett. 1997 Dec 9;120(2):149-56. https://www.ncbi.nlm.nih.gov/pubmed/9461031
9. Sammit, S., Owen, MJ, Evand, J., et al (1995). Cannabis, COMT and psychotic experiences. Br J Psychiatry. 2011 Nov;199(5):380-5. https://www.ncbi.nlm.nih.gov/pubmed/21947654
10. Siniscalco, D., Bradstreet, J., et al (2014). The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages. Journal of Neuroinflammation 2014, 11:78. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996516/
11. Basavarajappa, B. S. (2007). Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity. Current Neuropharmacology, 5(2), 81–97.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139910/
12. Cabral GA1, Staab A.(2005). Cannabis effects on the immune system. Handb Exp Pharmacol. 2005;(168):385-423. https://www.ncbi.nlm.nih.gov/pubmed/16596782
13. DiForti, M., et al (2012). Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry. 2012 Nov 15;72(10):811-6. https://www.ncbi.nlm.nih.gov/pubmed/22831980

WHAT’S THE DIFFERENCE BETWEEN CBD ISOLATE AND FULL SPECTRUM CBD?

Due to its non-psychoactive healing properties, Cannabidiol (CBD) has become a very popular option for patients seeking a natural alternative to treat conditions such as chronic pain, anxiety, epilepsy, and more. As patients start to understand how CBD can be used to alleviate their symptoms, they are often faced with a choice between using products made from CBD Isolate or Full Spectrum CBD. So, what exactly is the difference between the two?
When CBD is referred to as full spectrum or whole plant CBD, it means that the CBD contains all other cannabinoids found in the marijuana plant including CBN (Cannabinol), CBG (Cannabigerol), and THCV (Tetrahydrocannabivarin), to name a few. And yes, along with these cannabinoids, Full Spectrum CBD also contains trace amounts of THC (Tetrahydrocannabinol), but in very low concentrations (up to .3%), resulting in very minimal psychoactive stimulation. CBD Isolate, on the other hand, is simply purified CBD that has been extracted from the marijuana plant and isolated from the other cannabinoids. So why is this important, and why would a patient choose one over the other? Let’s continue!

UNDERSTANDING THE BENEFITS OF DIFFERENT CANNABINOIDS

As shown in the chart above, each cannabinoid offers different benefits for a wide variety of ailments. Notably, CBD offers nearly all the benefits of each cannabinoid combined. While there is no debate that CBD offers the most benefits compared to any single cannabinoid, many wonder if CBD alone is more effective for treating ailments than all the cannabinoids combined.

CBD VS. FULL SPECTRUM CBD: WHICH IS MORE EFFECTIVE?

It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage.
While full spectrum CBD has ultimately proven to be more effective than CBD Isolate and can be used to effectively treat a wide variety of ailments, it does not discredit the effectiveness of CBD Isolate. There are a wide variety of situations when CBD isolate would be preferred over Full Spectrum CBD. For example, you may not necessarily need the full capabilities of Full Spectrum CBD, or if you aren’t legally allowed to use THC. It is also important to note that other cannabinoids may cause negative reactions when isolated CBD wouldn’t (if the condition you are suffering from is critical, we definitely advise you speak to a medical consultant before trying out any version of CBD).
As researchers continue to study the marijuana plant, we will learn more and more about these amazing cannabinoids and what they can do for us. If you’d like to view current research on how CBD and the other cannabinoids benefit different conditions, visit our repository of medical research that covers over 50 medical conditions: click here.
We hope that this article helped you understand the difference between CBD Isolate and Full Spectrum CBD, and if you have any questions or comments, we invite you to engage in the comments section below!

Thanks for reading and stay happy!

by Betty Yu

Researchers Investigate Cannabis Compounds to Treat Dementia

LAFAYETTE (KPIX) — A few times a day, 92-year-old Lucy Hanson takes a little capsule; in it is medical marijuana.

“They call it my happy pill and I call it my happy pill,” Hanson laughs.

It’s hard to believe when you talk to her now but, four years ago, Lucy was confused, falling down and speaking gibberish. She often lay in bed and would make no eye contact with her family or friends.

Her daughter brought her to a neurology clinic where specialists ran diagnostic tests and looked over all of her medications. They said the problems were not with her prescription drugs.

“They came back with a diagnosis of advanced dementia,” said her youngest daughter Tania Hanson DeYoung, adding “We thought we’d only have her for another six months.”

Enter Eloise Theisen, a geriatric nurse-practitioner who specializes in medical cannabis. Theisen is on the team at Green Health Consultants.

“Seniors are the fastest-growing demographic of cannabis users,” explained Theisen.

Theisen weaned Lucy off some medications and then put her on cannabidiol or CBD, for short.

CBD is a non-intoxicating form of cannabis that’s derived from hemp.

The change in Lucy was remarkable.

“Lucy’s had one of the most dramatic responses,” remarked Theisen.

“I got my mother back,” said Hanson’s daughter Tania.

“I know it sounds crazy but it seems like I was given back a life,” exclaimed Hanson.

KPIX has spoken to several different caregivers who recount similar experiences.

“I would give her a couple of hits of cannabis off a little glass pipe,” said Steve DeAngelo, who heads up Harborside, a medical cannabis dispensary.

DeAngelo’s late mother had Alzheimer’s, a progressive neuro-degenerative disease. He says cannabis helped her.

“She would stop frowning, she would start smiling and she would be less physically agitated,” said DeAngelo.

“It was really an overnight miracle,” exclaimed Basil Shaaban.

Basil and his brother Farah saw it with their own eyes. Their mother Tagrid was diagnosed with early-onset Alzheimer’s Disease about eight years ago.

As her symptoms worsened, doctors put her on anti-psychotic drugs.

“She was already in a pretty fragile state and these drugs came in and they literally destroyed her … whatever she had left of her,” said Farah Shaaban.

The brothers convinced family members to let them try CBD. Their mother’s personality returned and her agitation and insomnia disappeared.

“We were so relieved that she would finally be able to sleep,” Farah Shaaban remembers.

Tagrid is off anti-psychotics and her doctors were curious.

“Now a year later they’re consulting with us to try to understand what it is that we did and how they can learn from it and apply it in their own practice,” Basil Shaaban said.

The Shaaban brothers tried different strains of CBD and finally settled on one that worked the best: they call it “Tagrid’s Strain.”

Now, an intriguing preliminary report out of a prestigious research institute suggests cannabis may actually protect the brain.

“We were looking at botanicals,” said Dr. David Schubert, with the Salk Institute for Biological Studies in La Jolla.

Schubert studies neuro-degenerative disorders like Alzheimer’s.

“It’s just a really horrible disease. There is no reasonable therapy. There is nothing that can slow it down,” said Schubert.

In a dish in his lab, Schubert and his team grew nerve cells taken from a human brain.

They were altered to produce high levels of a toxic protein linked to Alzheimer’s disease.

The protein known as amyloid beta builds up within the neuron, causing inflammation, and killing it.

“So inflammation is a major driving force,” said Schubert.

The scientist then exposed the neurons to cannabis. He found cannabis cleared away the toxic protein.

It stopped the inflammation from inside the neuron and that allowed the brain cells to survive.

“It’s a very important discovery,” says Dr. Michael Weiner, who conducts Alzheimer’s research at the San Francisco VA Medical Center.

“This is a very promising area of research and should be explored,” said Weiner.

Weiner said until good clinical studies are done in humans, people should not try to take marijuana for a medical benefit.

One major problem: cannabis remains illegal under federal law, making it tough to study.

Schubert believes that has slowed progress.

“It’s slowed it down a tremendous amount,” Schubert said.

Lucy Hanson’s daughter is convinced.

“She’d be dead if we had waited for it to be carefully studied, my mom would be dead,” said Tania.

As for Lucy? “Don’t you dare take it away from me,” she laughed.

LINKS:

Alzheimer’s Disease & Dementia

www.alz.org

Cannabidiol Explainer

https://www.projectcbd.org/about/what-cbd

Green Health Consultants

http://www.greenhealthconsultants.com

Harborside

Home Page

Salk Institute for Biological Studies

www.salk.edu

DR. TITUS INSIGHTS: NSAIDS, FLAVONOIDS, AND AUTISM

Flavonoids are a group of phytonutrients most remarkably known for providing vivid non-green pigments to the plant kingdom, such as the blue in blueberries, the red in red roses and the purple in your Granddaddy Purp Cannabis. Alongside cannabinoids (such as THC and CBD) and terpenoids (such as myrcene and limonene), flavonoids in cannabis also produce a range of effects. Commonly grouped together, flavonoids combine together to supplement the other cannabis phytonutrients – and play a highly bioactive role in the plant’s consumption and cultivation.

When cannabis is consumed, flavonoids contribute to the color, taste, smell, entourage effect and overall sensory experience. While contributing to health benefits of the cannabis plant, these flavonoids also have a great reputation among the wellness community for providing a range of health benefits to humans.

Federal prohibition has prevented more study and research in regards to cannabis related flavonoids; however, this class represents one of the largest nutrient families known to science. Over 6,000 individual flavonoids have been identified and many are found in the fruits, vegetables and herbs that we routinely consume.

A type of flavonoid found in green tea and cacao known as “catechins” is known to provide antioxidant and cardiovascular health benefits, while also providing favorable effects upon cholesterol levels in humans. Another flavonoid, known as “quercetin” which is readily available in many fruits and vegetables (as well as in cannabis) is known for having potential antioxidant and anti-viral properties.

Certain flavonoids are unique to the cannabis plant and are now referred to as “cannaflavins” and research is underway to distinguish cannaflavins from more common flavonoids. Recently it was discovered that a cannaflavin known as “Cannaflavin-A” inhibits PGE-2, a prostaglandin responsible for inflammation – similar to the effect of NSAIDs like aspirin. The research study showed that “Cannaflavin-A” reduces inflammation and is exponentially more powerful than aspirin.

Cannaflavin-B and Cannaflavin-C are being studied as well. Researchers continue their work on more common flavonoids in plants that also appear in cannabis: such as beta-sitosterol, vitexin, isovitexin, apigenin, kaempferol, quercetin, luteolin and orientin – whether these flavonoids enhance or reduce certain effects of cannabis based cannabinoids and/or terpenoids.

Because of the high level of anti-inflammatory properties that support detoxification of tissue-damaging molecules, flavonoids consumption if often associated with reduced risk of certain cancers, most notably lung and breast cancer. Flavonoids are readily found on the cured leaves and flowers of cannabis and through advanced extraction techniques, we may soon be combining cannabinoids with a ribbon of “flav” oil.

Here is a list of some major flavonoids, potential therapeutic effects and their corresponding vaporization temperatures:

Beta-sitosterol: 273 degrees F; anti-inflammatory
Apigenin; 352 degrees F; estrogenic, anxiolytic, anti-inflammatory
Cannaflavin-A; 360 degrees F; anti-inflammatory
Quercetin; 482 degrees F; antioxidant, antiviral
More info: https://www.merryjane.com/health/flavonoids-cannabis

Every cancer patient’s nightmare is the high toxicity of chemotherapy, with its horrible side effects. Chemotherapy kills cancer cells; it can also kill the patient. Is this something that cannot be helped? Is it inevitable?

If you ask your MD or oncologist, they will tell you with a sad smile that unfortunately, for the present moment, it is beyond the power of medical science to make chemotherapy selectively target cancer cells.

Nothing could be further from the truth!

There are two legal, safe, effective and inexpensive methods to make chemotherapy selective to cancer cells. One is IPT, described in another report on this website. The other one is DMSO potentiation. Both methods are completely ignored and stubbornly resisted by the medical establishment, despite irrefutable and overwhelming proof of efficacy and safety. In other words, when your oncologist prepares a chemotherapeutic course for you, it will be highly toxic and damaging to your body, despite the fact that methods exist – and are being legally practiced by medical doctors – that reduce the toxicity of chemotherapy virtually to zero.

What is DMSO?

Short for Dimethyl Sulfoxide, DMSO is a 100% natural substance; a byproduct of the lumber industry, which supplies it to the pharmaceutical industry for veterinary and human use. Already 40 years ago, it was discovered that dimethyl sulfoxide (DMSO) had a very high affinity for cancer cells. In other words, DMSO targeted cancer cells.

DMSO could bind to other substances, and still target cancer cells. It is one of the most powerful carrier/solvent known to science. It is able to bind to certain types of molecules, and then carry these molecules inside cancer cells.

The original scientific study which first proved this is the following:
“Haematoxylon [a dye] Dissolved in Dimethylsulfoxide [DMSO] Used in Recurrent Neoplasms [i.e. cancer cells or tumor cells],” by E. J. Tucker, M.D., F.A.C.S., and A. Carrizo, M.D. in International Surgery, June 1968, Vol 49, No. 6, page 516.

MEDICAL SCIENCE KNOWS SINCE 1968 THAT THE SELECTIVE TARGETING OF CANCER CELLS IS POSSIBLE, USING A SAFE AND INEXPENSIVE AGENT.

The study had been carried out by Eli J. Tucker, M.D. and A. Carnizo, M.D. In the study it was shown that DMSO targeted cancer cells, as the DMSO carried the haematoxylon dye into the cancer cells. It has also been shown that DMSO is able to revert cancer cells into normal cells. The study involved 37 human pre-terminal patients. The results of the study were declared “insufficient evidence” by the hospital’s review committee, and the study has been completely ignored by the mainstream medical establishment.

From the study:

In this series of 37 preterminal cases of malignancy that were treated with dimethylsulfoxide and Haematoxylon therapy, there was an improvement in 70.5 percent of the cases when used with combined current cancer therapeutic agents. These agents included surgery, radiation, 5-fluonouracil, methotnexate and thio-tepa. There was improvement in only 5.4 percent of those cases treated with the above measures without the use of dimethylsulfoxide and Haematoxylon.

The most striking results were observed in the two cases of large-cell lymphosarcoma and two cases of malignant giant-cell tumor of the bone. There was complete regression in both of the cases of large-cell lymphosancoma with no recurrence to date. There was also complete regression in one case of malignant giant-cell tumor of the femur with no recurrence to date and one case of a highly malignant giant-cell tumor of approximately one third of the femur which is still in a state of regression with bone regeneration.
With DMSO the improvement was 70.5 percent, without DMSO it was 5.4 percent. This has been the first human trial, using experimental procedure without any previous experience, and without the highly refined DMSO that has since been developed for medical use.

Since then, countless research studies have been carried out in many countries by medical research scientists. More than 40,000 articles have been published on the chemistry of DMSO in conjunction with thousands of laboratory studies, and world wide, there are over 11,000 articles on DMSO’s medical and clinical implications from some 125 countries. On the internet, in PubMed, the word, DMSO, brings up 15,478 research articles, the term, DMSO cancer, brings up 2,539 research articles.

Dr. Stanley Jacob MD, the ” Father of DMSO”, researched DMSO for decades, and written several books about it. Dr. William C. Douglass, MD – voted “Doctor of the Year” by the National Health Federation – personally saw so much promise with DMSO, he gave a three-day medical conference comprised of DMSO experts from around the world.

Writes Dr. Ron Kennedy, M.D., at www.medical-library.net:

When you consider the fact that DMSO is not a new and patentable drug, is cheap, safe and effective, and knowing what you should know about the medical establishment in the U.S., you could predict with your eyes closed that there is a propaganda campaign against DMSO. The FDA has done nothing except drag its feet in DMSO research since October 25, 1963 when the first research application to study DMSO was filed with that agency.

From http://www.bronzengids.nl/health/:

The FDA decided that DMSO was a dangerous drug and notified all the drug companies involved in DMSO research (Squibb, Syntex, Merck) to halt all clinical trials. Then they issued press releases that DMSO caused cataracts even though DMSO had never caused cataracts in any study, animal or human. On the contrary, research has shown that DMSO improves vision and is an effective treatment for retinitis pigmentosa and macular degeneration. The FDA used the bogus issue of eye damage for several decades to hold back DMSO. DMSO is seven times safer than aspirin yet has been persecuted for decades by the FDA.
See book: The Persecuted Drug – The Story of DMSO by Pat McGrady Sr.(available at Amazon).

DMSO was first reported in 1963 by Stanley Jacob, M.D. of the University of Oregon Medical School, former head of the organ transplant program at Oregon Health Sciences University in Portland. Jacob claimed that DMSO could penetrate skin and produce local analgesia, decrease pain, and promote healing of injured tissue. According to Jacob, more than 40,000 articles on its chemistry have appeared in scientific journals, which, in conjunction with thousands of laboratory studies, provide strong evidence of a wide variety of remarkable properties.

DMSO is one of the most studied but least understood pharmaceutical agents of our time – at least in the United States. Doctors around the world prescribe DMSO for a variety of ailments, including pain, inflammation, scleroderma, interstitial cystitis, and arthritis elevated inter-cranial pressure. Millions of patients were treated with it, without a single reported case of fatality, or serious injury, yet it continues to be ignored decade after decade by conventional medicine.

DMSO binds with water and changes the structure of the water within the cell, which results in the healing of cellular damage. This also increases the permeability of the cell membrane, causing a flushing of toxins from the inside of the cell. DMSO also improves immune function, decreases allergic reactions, increases immunity to infections, prohibits cancer growth, and decreases the potency of toxins. DMSO crosses the blood-brain barrier, and is an excellent agent to help transport other substances throughout the body.

When used for pain relief, chronic pain patients often report relief to a degree they had not been able to obtain from any other source. The anti-inflammatory and pain relief properties of DMSO have made it the most widely used, approved treatment for interstitial cystitis (irritation of the urinary tract) in the world. The treatment is FDA approved.

DMSO also reduces inflammation by several mechanisms. It is an antioxidant – a scavenger of the free radicals that gather at the site of injury. DMSO also stabilizes membranes and slows or stops leakage from injured cells.

Stephen Edelson, MD, F.A.A.F.P., F.A.A.E.M., who practices medicine at the Environmental and Preventive Health Center of Atlanta, has used DMSO extensively for 4 years. “We use it intravenously as well as locally”, he says. “We use it for all sorts of inflammatory conditions, from people with rheumatoid arthritis to people with chronic low back inflammatory-type symptoms, silicon immune toxicity syndromes and any kind of autoimmune process.”
What is the significance of DMSO in the fight against cancer? What does this substance mean to the cancer patient?

It means that a number of safe and effective cancer treatments can be designed that otherwise would not even exist.

DMSO is a superb, non-toxic solvent/carrier. Writes Dr. Morton Walker, MD, in his book, DMSO – NATURE’S HEALER (Amazon):

” As a penetrating carrier of drugs, DMSO is unsurpassed. It easily carries necessary pharmaceuticals to any part of the body for a therapeutic effect. It passes through cellular membranes and tissues. It is invariably able to penetrate endothelial coatings of the arterial walls, meninges of the brain, healthy skin, mucous membranes, and other tissues. ”

This enables DMSO to turn highly toxic treatments into benign, non-toxic ones. It also enables it to potentiate substances, elevating them to the level of powerful and safe anti-cancer agents. Let us take a look at these, one by one.

Please note: The below description of possible uses of DMSO are given as educational and experimental information, not as medical advice. Always discuss your therapeutic plans with a licensed health care practitioner. The following information has been obtained from public domain sources, as well as through interviews with research scientists and licensed medical practitioners.

Having said that, I’ll also add this: In my opinion, DMSO potentiation brings a revolution into medicine, because the individual who is seeking a solution better than the one offered by his or her oncologist, is free to try out non-toxic, non-prescription and non-invasive methods, without spending a fortune. This brings us, as patients, a step closer to medical freedom.

DMSO – intravenously, all by itself
DMSO – topically, all by itself
DMSO – orally, all by itself
DMSO — IPT (intravenous)
DMSO — chemotherapy (intravenous)
DMSO — nano-silver (topical/oral)
DMSO — cesium chloride (topical/oral)
DMSO — zeolite (topical/oral)
DMSO — ellagic acid (topical/oral)
DMSO — squalene/squalamine (oral)
DMSO — sodium bicarbonate (intravenous)

In the following treatment modalities, DMSO is regarded both as a carrier and as a healing substance. The fact that DMSO is inexpensive and safe makes it possible and realistic for the cancer patient to experiment with different protocols. Some may claim that these protocols are bizarre. Personally, I cannot imagine any treatment more bizarre than the one that introduces deadly poisons into the body, and has been proven obsolete, barbaric and ineffective through almost a century-long use.

DMSO – intravenously, all by itself
DMSO is a potent anti-cancer agent all by itself. At the present moment, there is only one clinic in the United States that offers “stand alone” intravenous DMSO treatments to cancer patients, administered and supervised by experienced medical doctors. Although they use various treatment modalities, their central cancer therapy is based on intravenous DMSO, where DMSO is not used as a carrier or potentiator, but as the main drug of the treatment. Click here for further details on the clinic.

DMSO – topically, all by itself
According to Dr. Walker, M.D., DMSO as a penetrating substance is unsurpassed. “It passes through cellular membranes and tissues. It is invariably able to penetrate endothelial coatings of the arterial walls, meninges of the brain, healthy skin, mucous membranes, and other tissues.” What does this tell us? It suggests that when injections or intravenous infusion are not available, DMSO, as an anti-cancer agent, can be introduced into the body safely and effectively through the skin. This is being done for sport injuries, arthritis, shingles, etc. by millions of people since more than 30 years. Here is how someone who has developed and patented a special DMSO formula for health purposes, including his and his family’s aches and pains, describes its topical use:

(The product these instructions refer to is a liquid solution called DMSO.BZ. It is an odorless clear liquid, similar to water. Please note that the developer of this formula does not claim that the product is a cancer treatment.)
Apply the solution with a cotton ball, pad, or even the fingers, to the area to be treated. Put on an ample coating, but not enough that it drips off, and cover the areas surrounding the injured area also, for a couple of inches. If you wish more rapid absorption, you can softly rub the area. If you choose to do this, don’t rub too much, or too hard, as you can irritate the skin. If you use your fingers, which I do a lot, you don’t even have to wash it off – just rub it into your hands. It helps them and aids the tissues and joints, so why waste it?

Don’t contaminate the bottle. Always pour some solution into a small glass, cup, or other container, and apply from this container. You don’t have to throw out the cotton ball, or pad after each application- just drop it in the glass with the solution you poured out, until you are going to apply it again later. If you want to be extra safe, cover the container with some plastic wrap between applications. I don’t bother with this, but it is not a bad idea, as the DMSO can absorb things from the air.

Within a few minutes you will notice the solution being absorbed into the skin. If you do notice some stinging (this may be accompanied by some redness), especially in very tender areas, such as the neck and face, it usually goes away in just a few minutes.

The sooner you apply the solution to the injured area, after injury, the quicker the healing process can begin, and some of the pain and tissue damage can actually be curtailed, and much of the bruising eliminated.

After the initial application, an additional application can be made after one half hour to one hour. You can continue applying the solution thereafter, every hour, or several hours, until the desired relief is obtained. This is quite an individual thing, and varies from injury to injury and from area to area, and, sometimes, even person to person. You can, and will, experiment on yourself and you will shortly determine what works for you. If you have chronic arthritis, or other pain, you may end up using an application, or two, every day to ease the pain, or keep the pain away entirely.

It would be hard to use too much of my DMSO solution, as it is classified as one of the safest products known. DMSO is naturally present in many of our food products and it has even been conjectured that it most likely exists naturally in human tissue. It is also stated that its derivative, MSM is definitely found at the cellular level (see the literature). If you use it too often on any given area, or rub too hard, about the only problem you will incur is a little burning and redness. After several days, though this is rare, except in the most tender areas, you may also notice some of the surface skin peeling, or flaking off, just like in mild sunburn.

If you do put it on too often, rub too hard, or use it on a very tender, thin skinned area, and get the burning sensation and redness, you may also notice some itching – yes, just like in a case of mild sunburn. If this occurs you can use some pure, high quality, skin cream, or plain old honey. If you use skin cream, just make sure it does not have many chemical additives, as they will also be absorbed into the skin, if you are continuing to apply the dmso solution.

At the bottom of this page you will find further information on this product. (Please note: I do not receive any commission or payment from any of the manufacturers, distributors, doctors and clinics listed on this website.)
The distributor is also available for consultation – free of charge – with his customers, but please, do not try to discuss cancer treatments with him, as he is not licenced to give medical advice. However, he can give you practical advice on how to handle the product.

You have seen earlier that there is a clinic in the USA where cancer is being treated by intravenous DMSO. Now we are looking at a treatment that uses DMSO through the skin to fight cancer. In order to bring enough DMSO into the body to make a difference, the solution can be applied repeatedly, in every two-three hours if needed. It can also be applied to relatively large areas on the body. Remember that DMSO actively and selectively seeks out cancer cells. This has been proven beyond doubt in animal and human studies. The biochemical reasons are not well understood, but the fact remains that DMSO targets cancer cells. It is also able to reach brain tumors because it is capable of passing through the blood/brain barrier. This has also been proven. According to the clinic where DMSO is infused intravenously to cancer patients, the treatment is used very successfully for aggressive brain tumors.

Should DMSO be used alone, by itself, or should it be combined with another anticancer agent? This has to be decided by the patient him/herself. An experienced naturopath or holistic doctor should be consulted before embarking on a treatment course. The potential combinations, listed below, may help in the decision. These therapies are by no means the only ones that can be tried. For example, at the clinic mentioned above, laetril is being occasionally used together with DMSO. There are many other variations that could be explored. Here, I only mention anti-cancer substances that are supported by sufficient scientific and clinical evidence, and where we are certain that they can be used with DMSO.

Not every anti-cancer remedy or substance can be combined with DMSO. Some will neutralize its effects, others will cause complications. For example, it is not clear whether it can be used in conjunction with Cantron or Protocel. It is better not to try.

To be absolutely certain that DMSO will not cause nausea, it is better not to use it with an empty stomach. This doesn’t mean that one should eat before each application, but the stomach should not be entirely empty.

DMSO – orally, all by itself
The premise is the same as with topical application, with one difference. The topical application is not likely to cause serious side effects; the oral ingestion has limits, set by how much DMSO is accepted by the stomach. People with a sensitive stomach may find that more than 2-3 tablespoonful will result in nausea or cramps. For maximum and fastest results, DMSO may be taken in small quantity (2 tablespoon a day) over and above the topical application. Never take it on an empty stomach. Eat a good breakfast or a snack before. If there is an allergic reaction to DMSO (not likely, but not impossible), stop using it, and choose another therapeutic approach.

Please note: DMSO in therapeutic quantites has zero toxicity. Should anyone drink several quarts of it, it may cause severe injury, even death. Although it is said to be seven times less toxic than aspirin, at the megadose level it is dangerous. Do not leave it out where children can reach it.

DMSO combined with IPT
In Insulin Potentiation Therapy the chemotherapeutic agents are carried into the glucose-starved cancer cells, thus selectively targeting them. Adding DMSO to the intravenous procedure enhances the targeting. Most doctors who offer IPT feel that this is not necessary, it would only duplicate the insulin’s results. This argument seems to ignore the well-known fact that DMSO has a powerful healing effect on abnormal cells all by itself. If the clinic offers both IPT and DMSO, combining the two can be discussed with the doctor.

DMSO Potentiated Chemotherapy
In this treatment, DMSO is used as a carrier to drag chemotherapeutic substances into cancer cells. Like in IPT, the objective is the selective targeting of cancer cells, using DMSO intravenously, together with the chemotherapy. Here, DMSO replaces the insulin as a targeting agent, although the biochemical procedure is not the same. In IPT, the insulin creates a condition where the chemo can be carried into the cells with the glucose solution. With DMSO, it is different. DMSO selectively seeks out cancer cells, acting like a “trojan horse” for the chemo.

DMSO Potentiated Nano-silver
This is a topical treatment, not intravenous.
Nano-silver is a new, powerful anti-microbial silver solution, where the size of the silver particles is a few nano-meters. At this size, the particles are a thousand times smaller than the colloidal particles in colloidal silver solutions, and they behave quite differently in the organism. For more on nano-silver, see the report.
From the report: Nano-silver doesn’t directly kill cancer cells; it kills bacteria, viruses and fungi. Cancer cells survive by fermenting glucose. Where there is fermentation, there is yeast. This means that there is a microbial presence within each cancer cell. If the fermenting bacteria die, the cancer cell either changes its metabolism to a normal one, or it also dies. In both cases, mission has been accomplished.

Nano-silver is small enough to penetrate a cancer cell. Once inside, it is believed that it will kill any microbial or viral presence. For this to happen, the nano-particles must be guided into the cancer cells. This is where DMSO comes into the picture. It selectively targets cancer cells, and it will “drag” the nano-silver into those cells. In this treatment, both the DMSO and the nano-silver solutions are applied topically (on the surface of the skin).

The treatment is completely non-toxic. Nevertheless, when applying DMSO to the skin, certain rules must be followed. Do not wear latex or rubber gloves, because DMSO will carry molecules from the material into your blood stream. Do not permit alcohol, soap, etc. to come in contact with the DMSO. If you use topically liquid DMSO, you can mix it with equal amount of nano-silver solution, and apply it to the skin. Do not rub it. Let it dry, then after 10 minutes, wipe it off gently.

The complete success of this treatment depends on the nano-silver’s ability of killing the microbe in the cancer cell. It has not yet been proven that nano-silver can kill all possible kinds of cancer microbes. Some cancers harbour viruses, some fungi, others bacteria. It is possible that all these microbial forms are the different pleomorphic stages of the same original microbe. If the microbe in the cancer cell is able to resist silver, the cancer cell will not be harmed by the silver. It has been demonstrated with colloidal silver that there are bacteria that do not respond to it, although they are rare. The good news is, even in such case, the DMSO, all by itself, will weaken or eliminate a large percent of the cancer cells it penetrates.

I have mentioned this possibility, not because I think that microbial resistance to nano-silver is likely, but because it has not yet been proven beyond doubt that such resistance is impossible, although the results from large number of tests so far are very positive. (See the nano-silver report.)

At the bottom of this page you will find sources where medical grade DMSO can be purchased.

The DMSO/nano-silver protocol can be done at home, without prescription or supervision; it is safe, simple, and inexpensive. Although the treatment can be repeated any number of times, it is advisable to apply the DMSO to the skin at different locations to avoid skin irritation.

Does nano-silver cross the blood/brain barrier? Can it be used to treat brain tumors? According the literature, nano-particles are able to pass through the BBB, however, so far no data is available based on controlled clinical trials.

From www.nanotechproject.org/file_download/53:

“At the nano-scale, cellular uptake mechanisms are different, as particles below 20 nm can be taken up by the endothelium skin layers and those below 10-50 nm can enter cells through receptor mechanisms. Nanoparticles have been found to cross the blood-brain barrier.”

From http://www.wisc.edu/fri/briefs/FRIBrief_Nanotech_Lit_Rev.pdf, FRI BRIEFINGS: Nanotechnology: A Brief Literature Review:

“Nanoparticles are readily taken up by many types of cells in vitro and are expected to cross the blood-brain barrier that excludes many substances that might harm the brain.”

As nano-silver is safe, inexpensive, and commercially available, brain cancer patients may want to add it to their protocol, even without irrefutable evidence concerning the blood/brain barrier.

DMSO Potentiated Cesium chloride (topical/oral)
The following information is posted on http://www.cancertutor.com/Cancer/Alkaline.html about the Cesium chloride/DMSO treatment:
“When it comes to treating advanced cancers, such as Stage IV cancers, fast growing cancers, cancers that have spread significantly, high fatality cancers, etc., if there were only one cancer treatment allowed to be used, this treatment would be the best choice. One reason for this is that it is the only “Stage IV” treatment that can be used at home for those who cannot take supplements or digest supplements.

While the Cesium Chloride / DMSO Protocol is extremely safe, given how powerful it is, before going on a Cesium Chloride Protocol, which must include DMSO, you need to DO YOUR HOMEWORK!!”

Yes, indeed, you do have to do your homework. The way to do that is to have phone consultations with the vendor, or doctor who can guide you in the Cesium protocol. These can be found in the Cesium report.

This is an immensely powerful cancer treatment, but the rules are strict, and they must be respected. The manner in which DMSO is used in this therapy will be explained by the consultant or guide who has experience with this method. The treatment itself is described in the Cesium report.

DMSO Potentiated Zeolite
Zeolite is available both in powdered and liquid forms. As a liquid, it can be mixed with DMSO, and used both topically and orally. According to the literature, zeolite easily crosses the blood/brain barrier. This means that DMSO is able to carry it into brain tumors. Zeolite is not a drug, no prescription is needed, and it is entirely non-toxic. For more info on zeolite, see the report.

DMSO Potentiated Ellagic acid
Ellagic acid is available in capsule and powder forms. For more information on Ellagic acid, see the report. Ellagic acid, whether taken as food, or as a supplement, is totally harmless. There is no toxic dose, and no side effects. At the same time, it is a powerful anti-cancer substance. In other words, it kills cancer cells. In its powdered form it can be mixed with DMSO, and taken orally, or applied topically.

DMSO Potentiated Squalamine
“Our results suggest that squalamine may be well suited for humans in the treatment of brain tumors and other diseases characterized by and dependent on new blood vessel growth,” says Henry Brem, director of neurosurgical oncology at Hopkins.

Squalamine is an immune molecule; it is a powerful angiogenesis inhibitor, originally isolated from the liver of dogfish sharks. Squalamine becomes vitally important when there is a fast growing tumor, blocking blood circulation or pressing on a vital organ. By stopping tumor growth, Squalamine permits a slow, gradual elimination of the tumor or tumors to take place. When a tumor is being destroyed, the immune system reacts by inflammation and swelling. This, in case of a brain tumor, can become a serious concern. Trials with laboratory animals indicate that Squalamine is capable of passing the blood/brain barrier.

As a supplement, squalamine is available in capsule form. Through a naturopathic doctor, it may be available in liquid form and of pharmaceutical grade. Squalamine capsules can be taken orally, followed immediately by DMSO, also taken orally. Do not take these substances on an emptry stomach.

Squalamine, as well as DMSO, is safe and non-toxic. No prescription is needed.

DMSO — sodium bicarbonate

This protocol combines Dr. Tullio Simoncini’s sodium bicarbonate treatment concept with DMSO, at the suggestion of the author of this website. The preliminary results are so impressive that the protocol promises to become the most effective cancer treatment in existence. The combination is only available at the Camelot Cancer Care clinic in Tulsa, Oklahoma, but any medical doctor or naturopath with a licence to give intravenous treatments can apply it.

DMSO is also one of the most powerful painkillers known to medical science.
From http://www.dmso.org/articles/information/herschler.htm:
DMSO is a drug that produced analgesia by acting both locally and systemically. The analgesia appeared to be unrelated to that produced by morphine although the two appear to be a comparable magnitude. DMSO had a longer duration of action than morphine, 6 hr vs 2 hr, respectively. (Haigler, H.J. Comparison of the analgesic effects of dimethyl sulfoxide and morphine. Ann. N.Y. Acad. Sci. 411: 19-27 (1983). )

DMSO is used by Dr. Donsbach at his Hospital Santa Monica (www.hospitalsantamonica.com) for much more than cancer, and he reports his patients respond quite well. [Donsbach, Kurt, DC, ND, PhD. Wholistic Cancer Therapy. San Diego: The Rockland Corporation, 1993] Donsbach feels that DMSO assists all the other therapies and agents he employs, and it is one therapy he administers to everyone with cancer: DMSO and hydrogen peroxide infusions. He also mentions a study at New York’s Mount Sinai Hospital where mice with leukemia were injected with DMSO and the leukemic cells began for function normally.

WARNING: Never use DMSO in an enema, never introduce it into the body rectally. If it is squirted in rectally, it will carry toxic fecal matter into the bloodstream through the intestinal wall.

Sources:

DMSO for oral and topical use: http://www.painease.com/ They mix DMSO with pure honey, which makes it much easier on the stomach, when taken orally. Also, they ship in a glass container.

https://jacoblab.com/OrderDMSO70.html The original DMSO made to Dr. Stanley W. Jacob’s exact specifications. This product is only for topical use. Do not swallow it.

http://www.herbalremedies.com/dmso.html I have no specific information on their DMSO products.

http://www.evitamins.com/product.asp?pid=4247 I have no specific information on their DMSO products.

Your doctor will have access to DMSO that is suitable for injections, or intravenous application, if your treament requires it.

Source credit; http://www.holisticcancersolutions.com/dmso_report.htm

BY VIOLA BRUGNATELLI · PUBLISHED MAY 5, 2015 · UPDATED OCTOBER 23, 2017

Highlights:

The endocannabinoid system is the most important physiologic system involved in establishing and maintaining human health
Sea squirts, tiny nematodes, and all vertebrate species share the endocannabinoid system as an essential part of life and adaptation to environmental changes
Currently, there are two recognised cannabinoid receptors: CB1, predominantly present in the nervous system, connective tissues, gonads, glands, and organs; and CB2, predominantly found in the immune system and its associated structures
Endocannabinoids are the substances our bodies naturally make to stimulate these receptors
Phytocannabinoids are plant substances that stimulate cannabinoid receptors

Contents of this article:

1) What is the Endocannabinoid System?

2) What are Cannabinoid Receptors?

3) What’s an endocannabinoid?

4) Synthetic Cannabinoids

5) Support & Copyright

The endocannabinoid system, named after the plant that led to its discovery, is the most important physiologic system involved in establishing and maintaining human health.

“As a physician, I am naturally wary of any medicine that purports to cure‐all.

Panaceas, snake‐oil remedies, and expensive fads often come and go, with big claims but little scientific or clinical evidence to support their efficacy.

As I explore the therapeutic potential of cannabis, however, I find no lack of evidence.

In fact, I find an explosion of scientific research on the therapeutic potential of cannabis, more evidence than one can find on some
of the most widely used therapies of conventional medicine. “

Dustin Sulak, DO
Maine Integrative Healthcare

What is the Endocannabinoid System?
The endogenous cannabinoid system, named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health.
Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells.

In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment.
Cannabinoids promote homeostasis at every level of biological life, from the sub‐cellular, to the organism, and perhaps to the community and beyond.
Hereʹs one example: autophagy, a process in which a cell sequesters part of its contents to be self‐digested and recycled, is mediated by the cannabinoid system.

While this process keeps normal cells alive, allowing them to maintain a balance between the synthesis, degradation, and subsequent recycling of cellular products, it has a deadly effect on malignant tumor cells, causing them to consume themselves in a programmed cellular suicide.

The death of cancer cells, of course, promotes homeostasis and survival at the level of the entire organism.

Find out better how cannabinoids are effective anti-tumoral agents and what therapy could assist you to fight cancer.

Endocannabinoids are also neuromodulators, allowing communication and coordination between different cell types.

At the site of an injury, for example, cannabinoids can be found

decreasing the release of activators and sensitizers from the injured tissue
stabilizing the nerve cell to prevent excessive firing
calming nearby immune cells to prevent release of pro‐inflammatory substances
Three different mechanisms of action on three different cell types for a single purpose: minimize the pain and damage caused by the injury.

Check out why cannabinoids are the best option for chronic pain, neuropathic pain or inflammatory pain.

What are Cannabinoid Receptors?
Sea squirts, tiny nematodes, and all vertebrate species share the endocannabinoid system as an essential part of life and adaptation to environmental changes.

By comparing the genetics of cannabinoid receptors in different species, scientists estimate that the endocannabinoid system evolved in primitive animals over 600 million years ago.

While it may seem we know a lot about cannabinoids, the estimated twenty thousand scientific articles have just begun to shed light on the subject.

Large gaps likely exist in our current understanding, and the complexity of interactions between various cannabinoids, cell types, systems and individual organisms can still offer novel ways to look at physiology and health.

The following brief overview summarizes what we do know, ( without getting over specific with terminology and mechanisms otherwise pedantic for general public)

Cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system.

endocannabinoid system activation signalling

When cannabinoid receptors are stimulated, a variety of physiologic processes ensue.
Currently, there are two recognised cannabinoid receptors: CB1, predominantly present in the nervous system, (is the most abundant G-protein coupled receptor of the CNS) connective tissues, gonads, glands, and organs; and CB2, predominantly found in the immune system and its associated structures.
Many tissues contain both CB1 and CB2 receptors, each linked to a different action.
There are many researchers (like myself and many others investigating novel receptors), speculating on a larger number of cannabinoid receptors, such as GPR55, that are also sensitive to lipid cannabinoids.
What is important to understand for the purpose of this article, is that endocannabinoids are the substances our bodies naturally make to stimulate these receptors, and that these are fundamental for life.

Life is not possible in those of us who do not have cannabinoid receptors: in fact, depleting the gene encoding receptor sequence (in order to obtain a cannabinoid knockout KO -/-), prevents embryo development and survival to birth.

What’s an endocannabinoid?
The two most well understood endocannabinoid molecules are called anandamide (from Sanskrit, bliss) and 2‐arachidonoylglycerol (2‐AG).
They are synthesized on‐demand from cell membrane arachidonic acid derivatives, have a local effect and short half‐life before being degraded by the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Chemically, endocannabinoids are eicosanoids (oxidised fatty acids) and for this reason during the International Cannabinoid Research Society symposium of 2014 at Baveno, Italy, it has been proposed to change the nomenclature of “endocannabinoids” to “eicosanoids” in order to prevent stigma for therapies that target the cannabinoid system, but clearly lack of the cannabis component. (This change has never taken place yet).

Phytocannabinoids are plant substances that stimulate cannabinoid receptors.

Most phytocannabinoids have been isolated from Cannabis sativa, but other medical herbs, such as Echinacea purpura, have been found to contain non‐psychoactive cannabinoids as well.

Delta‐9‐tetrahydrocannabinol, or THC, is the most psychoactive and certainly the most famous of these substances, but other cannabinoids such as cannabidiol (CBD) and cannabinol (CBN) and cannabinoid acids (THCA), are gaining the interest of researchers due to a variety of healing properties (that are further discussed here).

Interestingly, the Cannabis plant uses cannabinoids to promote its own health and prevent disease.

Cannabinoids have antioxidant properties that protect the leaves and flowering structures from ultraviolet radiation ‐ cannabinoids neutralize the harmful free radicals generated by UV rays, protecting the cells.
In humans, free radicals cause aging, cancer, and impaired healing, which can lead to a variety of pathologies, from neurodegenerative to immune disorders. Antioxidants found in plants have long been promoted as natural supplements to prevent free radical harm.
(Here you will find many antioxidant-rich recipes to include in your diet)

Synthetic Cannabinoids
Cannabinoids have also been synthesised, and whilst some remain mainly in the research domain (Usually those with long codes-like letters and numbers), several synthetic analogs of THC or THC+CBD combination are both prescribed for oral or sublingual intake. (We have a guide on these kind of products)
CBD or Raw CBD (+CBDa) is available in many Countries as food supplement due lack of restrictive prescriptions on non-psychoactive compound. (However, we recommend you to check certification of providers (as we outlined in this article: “The importance of Cannabinoid Analysis”, and if you are unsure get in touch with our team for consulting)

If you are interested to know which Countries approve medical use of these cannabinoids, and what phathologies have been authorized prescription, I suggest you to check here or watch this video.

In order to understand whether whole plant or single compound may be better for you, please read here.

This introduction to the Endocannabinoid System has been written thanks to the brilliant yearly review of recent scientific literature of “Emerging clinical applications of cannabis and cannabinoids” , by Paul Armentino, Deputy Diector of NORML (Check and support their work if you read from the States!) , they have a gift for concise and educational summary and I felt it was the best approach (compared to the peer-reviewed publication model I often adopt), in order to introduce the basics of the Endocannabinoid System.

All the information is indeed coming from an extensive work of review on the 15,899 articles on PubMed related to cannabinoids NORML does yearly, as well as a very interesting speech by Dr William Courtney during the ICRS 2014 annual symposium (check out his and his wife’s pioneering work with edible raw cannabis here) and my own understanding from previous years of studies and work on the topic.

If you want to delve in the topic, stay tuned for 2017 new articles either by signing in through the newsletter (I promise that you only receive a lovely once a month email, so no cluttering your inbox) or following us through the Facebook page or YouTube.
I am happy to read your comments and suggestions for new insights, so just leave them below.

Spread consciousness and smile more!

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